CDK5RAP3 Participates in Autophagy Regulation and Is Downregulated in Renal Cancer
Identifieur interne : 000984 ( Main/Exploration ); précédent : 000983; suivant : 000985CDK5RAP3 Participates in Autophagy Regulation and Is Downregulated in Renal Cancer
Auteurs : Jun Li [République populaire de Chine] ; Xinyi Hu [République populaire de Chine] ; Ming Su [République populaire de Chine] ; Hongliang Shen [République populaire de Chine] ; Wei Qiu [République populaire de Chine] ; Ye Tian [République populaire de Chine]Source :
- Disease Markers [ 0278-0240 ] ; 2019.
Abstract
Renal cancer is one of the most common malignant urological tumors; however, its diagnosis and treatment are not well established. In the present study, we identified that CDK5 regulatory subunit-associated protein 3 (CDK5RAP3), a putative tumor suppressor in many cancers, was downregulated in renal cancer tissues. Through loss- and gain-of-function experiments, we observed that the action of CDK5RAP3 in renal cancer cells was different in Caki-1 and 769-P cell lines. Knockdown of endogenous CDK5RAP3 in Caki-1 slightly increased cell viability, whereas overexpression of CDK5RAP3 in 769-P cells inhibited cell viability. In addition, we observed that CDK5RAP3 participated in the regulation of autophagy in renal cancer. Knockdown of CDK5RAP3 induced significant inhibition of autophagy in Caki-1 cells but not in 769-P cells. In contrast, overexpression of CDK5RAP3 significantly activated autophagy in 769-P cells, as evidenced by increased LC3-II levels. However, the LC3-II could not be altered by CDK5RAP3 overexpression in Caki-1 cells. These findings demonstrated that CDK5RAP3 is downregulated in renal cancer and may be associated with autophagy.
Url:
DOI: 10.1155/2019/6171782
PubMed: 31061682
PubMed Central: 6466961
Affiliations:
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Chine</country><wicri:regionArea>Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Hu, Xinyi" sort="Hu, Xinyi" uniqKey="Hu X" first="Xinyi" last="Hu">Xinyi Hu</name><affiliation wicri:level="3"><nlm:aff id="I1">Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Su, Ming" sort="Su, Ming" uniqKey="Su M" first="Ming" last="Su">Ming Su</name><affiliation wicri:level="3"><nlm:aff id="I2">Department of Clinical Laboratory, Peking University People's Hospital, Beijing, 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Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Tian, Ye" sort="Tian, Ye" uniqKey="Tian Y" first="Ye" last="Tian">Ye Tian</name><affiliation wicri:level="3"><nlm:aff id="I1">Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">Disease Markers</title><idno type="ISSN">0278-0240</idno><idno 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In the present study, we identified that CDK5 regulatory subunit-associated protein 3 (CDK5RAP3), a putative tumor suppressor in many cancers, was downregulated in renal cancer tissues. Through loss- and gain-of-function experiments, we observed that the action of CDK5RAP3 in renal cancer cells was different in Caki-1 and 769-P cell lines. Knockdown of endogenous CDK5RAP3 in Caki-1 slightly increased cell viability, whereas overexpression of CDK5RAP3 in 769-P cells inhibited cell viability. In addition, we observed that CDK5RAP3 participated in the regulation of autophagy in renal cancer. Knockdown of CDK5RAP3 induced significant inhibition of autophagy in Caki-1 cells but not in 769-P cells. In contrast, overexpression of CDK5RAP3 significantly activated autophagy in 769-P cells, as evidenced by increased LC3-II levels. However, the LC3-II could not be altered by CDK5RAP3 overexpression in Caki-1 cells. These findings demonstrated that CDK5RAP3 is downregulated in renal cancer and may be associated with autophagy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Linehan, W M" uniqKey="Linehan W">W. M. Linehan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, M" uniqKey="Sun M">M. Sun</name></author><author><name sortKey="Becker, A" uniqKey="Becker A">A. Becker</name></author><author><name sortKey="Tian, Z" uniqKey="Tian Z">Z. Tian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y. Shi</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mak, G W Y" uniqKey="Mak G">G. W.-Y. Mak</name></author><author><name sortKey="Chan, M M L" uniqKey="Chan M">M. M. L. Chan</name></author><author><name sortKey="Leong, V Y L" uniqKey="Leong V">V. Y. L. Leong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stav, D" uniqKey="Stav D">D. Stav</name></author><author><name sortKey="Bar, I" uniqKey="Bar I">I. Bar</name></author><author><name sortKey="Sandbank, J" uniqKey="Sandbank J">J. Sandbank</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, J B" uniqKey="Wang J">J. B. Wang</name></author><author><name sortKey="Wang, Z W" uniqKey="Wang Z">Z. W. Wang</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tints, K" uniqKey="Tints K">K. Tints</name></author><author><name sortKey="Prink, M" uniqKey="Prink M">M. Prink</name></author><author><name sortKey="Neuman, T" uniqKey="Neuman T">T. Neuman</name></author><author><name sortKey="Palm, K" uniqKey="Palm K">K. Palm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author><author><name sortKey="An, H" uniqKey="An H">H. An</name></author><author><name sortKey="Mayo, M W" uniqKey="Mayo M">M. W. Mayo</name></author><author><name sortKey="Baldwin, A S" uniqKey="Baldwin A">A. S. Baldwin</name></author><author><name sortKey="Yarbrough, W G" uniqKey="Yarbrough W">W. G. Yarbrough</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mak, G W Y" uniqKey="Mak G">G. W.-Y. Mak</name></author><author><name sortKey="Lai, W L" uniqKey="Lai W">W.-L. Lai</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Li, M" uniqKey="Li M">M. Li</name></author><author><name sortKey="Ng, I O L" uniqKey="Ng I">I. O. L. Ng</name></author><author><name sortKey="Ching, Y P" uniqKey="Ching Y">Y. P. Ching</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, H" uniqKey="Jiang H">H. Jiang</name></author><author><name sortKey="Luo, S" uniqKey="Luo S">S. Luo</name></author><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, J" uniqKey="Wu J">J. Wu</name></author><author><name sortKey="Jiang, H" uniqKey="Jiang H">H. Jiang</name></author><author><name sortKey="Luo, S" uniqKey="Luo S">S. Luo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, J X" uniqKey="Lin J">J. X. Lin</name></author><author><name sortKey="Xie, X S" uniqKey="Xie X">X. S. Xie</name></author><author><name sortKey="Weng, X F" uniqKey="Weng X">X. F. Weng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, C H" uniqKey="Zheng C">C. H. Zheng</name></author><author><name sortKey="Wang, J B" uniqKey="Wang J">J. B. Wang</name></author><author><name sortKey="Lin, M Q" uniqKey="Lin M">M. Q. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yun, C W" uniqKey="Yun C">C. W. Yun</name></author><author><name sortKey="Lee, S H" uniqKey="Lee S">S. H. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizumura, K" uniqKey="Mizumura K">K. Mizumura</name></author><author><name sortKey="Maruoka, S" uniqKey="Maruoka S">S. Maruoka</name></author><author><name sortKey="Shimizu, T" uniqKey="Shimizu T">T. Shimizu</name></author><author><name sortKey="Gon, Y" uniqKey="Gon Y">Y. Gon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, Y" uniqKey="Tan Y">Y. Tan</name></author><author><name sortKey="Gong, Y" uniqKey="Gong Y">Y. Gong</name></author><author><name sortKey="Dong, M" uniqKey="Dong M">M. Dong</name></author><author><name sortKey="Pei, Z" uniqKey="Pei Z">Z. Pei</name></author><author><name sortKey="Ren, J" uniqKey="Ren J">J. Ren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uddin, M S" uniqKey="Uddin M">M. S. Uddin</name></author><author><name sortKey="Mamun, A A" uniqKey="Mamun A">A. A. Mamun</name></author><author><name sortKey="Labu, Z K" uniqKey="Labu Z">Z. K. Labu</name></author><author><name sortKey="Hidalgo Lanussa, O" uniqKey="Hidalgo Lanussa O">O. Hidalgo-Lanussa</name></author><author><name sortKey="Barreto, G E" uniqKey="Barreto G">G. E. Barreto</name></author><author><name sortKey="Ashraf, G M" uniqKey="Ashraf G">G. M. Ashraf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, C Y" uniqKey="Sun C">C. Y. Sun</name></author><author><name sortKey="Zhang, Q Y" uniqKey="Zhang Q">Q. Y. Zhang</name></author><author><name sortKey="Zheng, G J" uniqKey="Zheng G">G. J. Zheng</name></author><author><name sortKey="Feng, B" uniqKey="Feng B">B. Feng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shah, S Z A" uniqKey="Shah S">S. Z. A. Shah</name></author><author><name sortKey="Zhao, D" uniqKey="Zhao D">D. Zhao</name></author><author><name sortKey="Hussain, T" uniqKey="Hussain T">T. Hussain</name></author><author><name sortKey="Sabir, N" uniqKey="Sabir N">N. Sabir</name></author><author><name sortKey="Mangi, M H" uniqKey="Mangi M">M. H. Mangi</name></author><author><name sortKey="Yang, L" uniqKey="Yang L">L. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, J F" uniqKey="Lin J">J. F. Lin</name></author><author><name sortKey="Lin, Y C" uniqKey="Lin Y">Y. C. Lin</name></author><author><name sortKey="Tsai, T F" uniqKey="Tsai T">T. F. Tsai</name></author><author><name sortKey="Chen, H E" uniqKey="Chen H">H. E. Chen</name></author><author><name sortKey="Chou, K Y" uniqKey="Chou K">K. Y. Chou</name></author><author><name sortKey="Hwang, I S" uniqKey="Hwang I">I. S. Hwang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ojha, R" uniqKey="Ojha R">R. Ojha</name></author><author><name sortKey="Singh, S K" uniqKey="Singh S">S. K. Singh</name></author><author><name sortKey="Bhattacharyya, S" uniqKey="Bhattacharyya S">S. Bhattacharyya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iachettini, S" uniqKey="Iachettini S">S. Iachettini</name></author><author><name sortKey="Trisciuoglio, D" uniqKey="Trisciuoglio D">D. Trisciuoglio</name></author><author><name sortKey="Rotili, D" uniqKey="Rotili D">D. Rotili</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serrano Oviedo, L" uniqKey="Serrano Oviedo L">L. Serrano-Oviedo</name></author><author><name sortKey="Ortega Muelas, M" uniqKey="Ortega Muelas M">M. Ortega-Muelas</name></author><author><name sortKey="Garcia Cano, J" uniqKey="Garcia Cano J">J. García-Cano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, M L" uniqKey="Li M">M.-L. Li</name></author><author><name sortKey="Xu, Y Z" uniqKey="Xu Y">Y.-Z. Xu</name></author><author><name sortKey="Lu, W J" uniqKey="Lu W">W.-J. Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kimmelman, A C" uniqKey="Kimmelman A">A. C. Kimmelman</name></author><author><name sortKey="White, E" uniqKey="White E">E. White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ou, L" uniqKey="Ou L">L. Ou</name></author><author><name sortKey="Lin, S" uniqKey="Lin S">S. Lin</name></author><author><name sortKey="Song, B" uniqKey="Song B">B. Song</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name></author><author><name sortKey="Lai, R" uniqKey="Lai R">R. Lai</name></author><author><name sortKey="Shao, L" uniqKey="Shao L">L. Shao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiu, W" uniqKey="Qiu W">W. Qiu</name></author><author><name sortKey="Su, M" uniqKey="Su M">M. Su</name></author><author><name sortKey="Xie, F" uniqKey="Xie F">F. Xie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kimura, T" uniqKey="Kimura T">T. Kimura</name></author><author><name sortKey="Takabatake, Y" uniqKey="Takabatake Y">Y. Takabatake</name></author><author><name sortKey="Takahashi, A" uniqKey="Takahashi A">A. Takahashi</name></author><author><name sortKey="Isaka, Y" uniqKey="Isaka Y">Y. Isaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grimaldi, A" uniqKey="Grimaldi A">A. Grimaldi</name></author><author><name sortKey="Santini, D" uniqKey="Santini D">D. Santini</name></author><author><name sortKey="Zappavigna, S" uniqKey="Zappavigna S">S. 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